Cisplatin

  • Brand Name : Cisplatin
  • Drug Class : Antineoplastics, Alkylating, Antineoplastics Platinum Analog
  • Medical Author : Sarfaroj Khan, BHMS, PGD Health Operations
  • Medical Reviewer :
  • _eael_post_view_count : 7

Brand Name: Platinol-AQ

Generic Name: Cisplatin

Drug Class: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog

What Is Cisplatin and How Does It Work?

Cisplatin is a prescription medication used to treat Metastatic Testicular Tumors, Advanced Bladder Cancer, and Metastatic Ovarian Carcinoma

  • Cisplatin is available under the following different brand names: Platinol-AQ

What Are Dosages of Cisplatin?

Adult dosage

Injectable solution

  • 1mg/mL

Metastatic Testicular Tumors

Adult dosage

  • 20 mg/m2/day IV for 5 days repeated every 3 weeks (in combination with bleomycin and etoposide)

Advanced Bladder Cancer

Adult dosage

  • 50-70 mg/m2 IV cycle every 3-4 weeks, depending on prior radiation therapy or chemotherapy
  • Heavily pretreated patients: 50 mg/m2/cycle initially; repeat every 4 weeks

Metastatic Ovarian Carcinoma

Adult dosage

  • 75-100 mg/m2 IV per cycle every 4 weeks with cyclophosphamide (600 mg/m2 IV every 4 weeks); administer sequentially 

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”.

What Are Side Effects Associated with Using Cisplatin?

Common side effects of Cisplatin include:

  • nausea, 
  • vomiting, 
  • loss of appetite, 
  • diarrhea, 
  • loss of taste, and
  • temporary hair loss

Serious side effects of Cisplatin include:

  • pain, burning, redness at the injection site 
  • numbness, tingling, coldness, and blue discoloration of the hands or feet, 
  • pain, redness, swelling of the arms or legs, 
  • loss of reflexes, 
  • loss of balance, 
  • trouble walking, 
  • muscle cramps or spasms, 
  • muscle weakness, 
  • neck or back pain
  • sores in mouth or tongue sores, 
  • joint pain, 
  • swollen legs or feet, 
  • mental or mood changes, 
  • headache, 
  • fast or irregular heartbeat, 
  • blood in urine, 
  • vomit that looks like coffee grounds, 
  • black or bloody stools, 
  • painful or difficult urination
  • lower back or side pain, 
  • vision changes, 
  • blurred vision, 
  • seeing colors differently, 
  • temporary vision loss, 
  • chest pain, 
  • a jaw or left arm pain, 
  • confusion, 
  • slurred speech, 
  • weakness on one side of the body, 
  • seizures, 
  • fever, 
  • chills, 
  • persistent sore throat
  • cough, 
  • rash, 
  • itching, 
  • swelling of the face, tongue, or throat, 
  • severe dizziness, and 
  • trouble breathing 

Rare side effects of Cisplatin include:

  • none 

This is not a complete list of side effects and other serious side effects or health problems may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

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