- Brand Name : Onfi
- Drug Class : , Anticonvulsants, Benzodiazepine
- Medical Author : Nazneen Memon, BHMS, PGDCR
- Medical Reviewer : Divya Jacob, Pharm. D.
- _eael_post_view_count : 4
What Is Clobazam and How Does It Work?
Clobazam is a prescription medicine used to treat seizures associated with Lennox-Gastaut syndrome (LGS).
What Are Dosages of Clobazam?
Adult and pediatric dosage
Scored tablet (ONFI, generic): Schedule IV
- 10mg
- 20mg
Oral suspension (ONFI, generic): Schedule IV
- 2.5mg/mL
Oral soluble film (Sympazan): Schedule IV
- 5mg
- 10mg
- 20mg
Geriatric dosage
- Starting dose should be 5 mg/day for all elderly patients and titrated according to weight, but to half the typical adult dose
- Additional titration to the maximum daily dose (depending on weight either 20 mg/day or 40 mg/day) may be started on day 21
- Administer daily doses of more than 5 mg in divided doses every 12 hours
Seizures
- Adult dosage
- Initiate at 5 mg orally every 12 hours; may titrate as tolerated up to 40 mg/day divided every 12 hours
- Pediatric dosage
- Children weighing less than 30 kg
- Starting dose: 5 mg orally once daily; titrate as tolerated up to 20 mg oral daily
- After 7 days, may increase to 5 mg orally every 12 hours; if needed, may increase to 10 mg orally every 12 hours after an additional 7 days
- Children weighing more than 30 kg
- Starting dose: 5 mg orally every 12 hours; titrate as tolerated up to 40 mg oral daily
- After 7 days, may increase to 10 mg orally every 12 hours; if needed, may increase to 20 mg orally every 12 hours after an additional 7 days
CYP2C19 poor metabolizers
Adult and pediatric dosage
- Starting dose should be 5 mg/day and titrated according to weight, but to half the typical dose
- Additional titration to the maximum dose (20 mg/day or 40 mg/day), depending on the weight group) maybe started on day 21
Dosage Considerations – Should be Given as Follows:
- See “Dosages”