Clobazam

  • Brand Name : Onfi
  • Drug Class : , Anticonvulsants, Benzodiazepine
  • Medical Author : Nazneen Memon, BHMS, PGDCR
  • Medical Reviewer : Divya Jacob, Pharm. D.
  • _eael_post_view_count : 4

What Is Clobazam and How Does It Work?

Clobazam is a prescription medicine used to treat seizures associated with Lennox-Gastaut syndrome (LGS).

  • Clobazam is available under the following different brand names: ONFI, Sympazan

What Are Dosages of Clobazam?

Adult and pediatric dosage

Scored tablet (ONFI, generic): Schedule IV

  • 10mg
  • 20mg

Oral suspension (ONFI, generic): Schedule IV

  • 2.5mg/mL

Oral soluble film (Sympazan): Schedule IV

  • 5mg
  • 10mg
  • 20mg

Geriatric dosage

  • Starting dose should be 5 mg/day for all elderly patients and titrated according to weight, but to half the typical adult dose
  • Additional titration to the maximum daily dose (depending on weight either 20 mg/day or 40 mg/day) may be started on day 21
  • Administer daily doses of more than 5 mg in divided doses every 12 hours

Seizures

  • Adult dosage
    • Initiate at 5 mg orally every 12 hours; may titrate as tolerated up to 40 mg/day divided every 12 hours
  • Pediatric dosage
    • Children weighing less than 30 kg
    • Starting dose: 5 mg orally once daily; titrate as tolerated up to 20 mg oral daily
    • After 7 days, may increase to 5 mg orally every 12 hours;  if needed, may increase to 10 mg orally every 12 hours after an additional 7 days
    • Children weighing more than 30 kg
    • Starting dose: 5 mg orally every 12 hours; titrate as tolerated up to 40 mg oral daily
    • After 7 days, may increase to 10 mg orally every 12 hours; if needed, may increase to 20 mg orally every 12 hours after an additional 7 days

CYP2C19 poor metabolizers

Adult and pediatric dosage

  • Starting dose should be 5 mg/day and titrated according to weight, but to half the typical dose
  • Additional titration to the maximum dose (20 mg/day or 40 mg/day), depending on the weight group) maybe started on day 21

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

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