- Brand Name :
- Drug Class : N/A
- Medical Author : John P. Cunha, DO, FACOEP
- Medical Reviewer :
- _eael_post_view_count : 6
What Is Custirsen and How Does It Work?
Custirsen is a drug in clinical trials used to treat prostate cancer and advanced or metastatic non-small cell lung cancer.
The addition of custirsen to first-line docetaxel and prednisone was reasonably well-tolerated, but overall survival was not significantly longer for patients with metastatic castration-resistant prostate cancer treated with this combination, compared with patients treated with docetaxel and prednisone alone.
Custirsen is available under the following different brands and other names: custirsen sodium, OGX-011, and CC-8490.
What Are the Dosages of Custirsen?
Dosages of Custirsen:
- Phase I trials determined the recommended dose of custirsen was 640 mg, with a maximum decrease of clusterin blood plasma occurring at this dose.
Dosage Considerations – Should be Given as Follows:
- Phase I trials determined the recommended dose of custirsen was 640 mg, with a maximum decrease of clusterin blood plasma occurring at this dose.
What Are Side Effects Associated with Using Custirsen?
Side effects of custirsen include:
- Low blood platelets (thrombocytopenia)
- Anemia
- Low white blood cells (leukopenia)
- Fever
- Fatigue
- Chills
- Hair loss
- Loss of appetite
- Side effects of custirsen in combined treatment with docetaxel:
- Shortness of breath
- Fluid buildup around the lungs
- Low white blood cells (neutropenia)
- Fatigue
- Inflammation of mucus membranes in the digestive tract
This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
What Other Drugs Interact with Custirsen?
If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
- Custirsen is in clinical trials. No information is available regarding drug interactions of custirsen.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.