Diphenhydramine

  • Brand Name : Benadryl
  • Drug Class : Antihistamines, 1st Generation, Antihistamines, Alkylamine Derivatives, Dermatologics, Other, Antihistamine/Decongestant Combos
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What Is Diphenhydramine and How Does It Work?

Diphenhydramine is a prescription medication used to treat the symptoms of Allergic Reaction, Insomnia, Cough, Motion Sickness, and Parkinsonism.

  • Diphenhydramine is available under the following different brand names: Benadryl, Benadryl Allergy Dye-Free LiquiGels, Children’s Benadryl Allergy, Children’s Triaminic Thin Strips Allergy, Alka-Seltzer Plus Allergy, Nytol, PediaCare Children’s Allergy, Simply Sleep, Sominex, QlearQuil Nighttime Allergy Relief, Tranquil Nighttime Sleep Aid, Unisome SleepGels, Unisom SleepMelts, ZzzQuil

What Are Side Effects Associated with Using Diphenhydramine?

Common side effects of Diphenhydramine include:

  • drowsiness, 
  • dry eyes, 
  • blurry vision, 
  • dry mouth, nose, or throat,
  • decreased urination, 
  • constipation, 
  • feeling restless or excited, and
  • day-time drowsiness or “hangover” feeling after night-time use

Serious side effects of Diphenhydramine include:

  • hives, 
  • difficulty breathing, 
  • swelling of the face, lips, tongue, or throat, 
  • severe drowsiness, and
  • painful or difficulty urinating

Rare side effects of Diphenhydramine include:

  • none

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

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