Elexacaftor-Tezacaftor-Ivacaftor

  • Brand Name : Trikafta
  • Drug Class : CFTR Correctors, CFTR Potentiators
  • Medical Author : Dr. Vinod Katiboina, Pharm. D.
  • Medical Reviewer : Divya Jacob, Pharm. D.
  • _eael_post_view_count : 9

What Is Elexacaftor-Tezacaftor-Ivacaftor and How Does It Work?

Elexacaftor-Tezacaftor-Ivacaftor is a prescription medication used for the treatment of cystic fibrosis (CF) in people aged 12 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

  • Elexacaftor-Tezacaftor-Ivacaftor is available under the following different brand names: Trikafta

What Are Side Effects Associated with Using Elexacaftor-Tezacaftor-Ivacaftor?

Common side effects of Elexacaftor-Tezacaftor-Ivacaftor include:

  • Headache
  • Diarrhea
  • Upper respiratory tract infection (common cold) including stuffy and runny nose
  • Stomach (abdominal) pain
  • Inflamed sinuses
  • Increase in liver enzymes
  • Increase in a certain blood enzyme called creatine phosphokinase
  • Rash
  • Flu (influenza)
  • Increase in blood bilirubin

Serious side effects of Elexacaftor-Tezacaftor-Ivacaftor include:

  • Pain or discomfort in the upper right stomach (abdominal) area
  • Nausea or vomiting
  • Yellowing of the skin or the white part of the eyes
  • Dark, amber-colored urine
  • Loss of appetite

Rare side effects of Elexacaftor-Tezacaftor-Ivacaftor include:

  • None 

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out. 

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

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