- Brand Name :
- Drug Class : N/A
- Medical Author : John P. Cunha, DO, FACOEP
- Medical Reviewer :
- _eael_post_view_count : 11
What Is Eplerenone and How Is It Used?
Eplerenone is an aldosterone receptor blocker, which is an antihypertensive, used to treat congestive heart failure after a heart attack, and is also used to treat high blood pressure (hypertension).
Eplerenone is available under the following different brand names: Inspra.
Dosages of Eplerenone
Dosage Forms and Strengths
Tablet
- 25 mg
- 50 mg
Dosage Considerations – Should be Given as Follows:
Hypertension (HTN)
- Adult and geriatric: Initial 50 mg orally once/day; may increase to 50 mg orally every 12 hours; may take up to four weeks for full therapeutic response; high blood potassium (hyperkalemia) may occur with doses greater than 100 mg/day
Heart Failure Post Myocardial Infarction (MI)
- Adult and geriatric: Initial 25 mg orally once/day; may titrate to maximum of 50 mg once daily within 4 weeks as tolerated
- Dose adjustments may be required based on potassium levels
Renal Impairment
- Contraindicated if CrCl less than 50 mL/min or serum creatinine greater than 2 mg/dL in males or greater than 1.8 mg/dL in females
Hepatic Impairment
- Dose adjustment not necessary
Dosing considerations
- In heart attack (myocardial infarction [MI]) congestive heart failure (CHF) patients taking a moderate CYP3A inhibitor, do not exceed 25 mg once daily; in patients with hypertension taking a moderate CYP3A inhibitor, initiate at 25 mg once daily; for inadequate blood pressure response, dosing may be increased to a maximum of 25 mg twice daily
- Pediatric: Safety and efficacy not established
Other Indications and Uses
- Improving survival of stable patients with LV systolic dysfunction (LVEF up to 40%) and congestive heart failure (CHF) after an acute heart attack (myocardial infarction [MI])