Eplerenone Inspra

  • Brand Name :
  • Drug Class : N/A
  • Medical Author : John P. Cunha, DO, FACOEP
  • Medical Reviewer :
  • _eael_post_view_count : 11

What Is Eplerenone and How Is It Used?

Eplerenone is an aldosterone receptor blocker, which is an antihypertensive, used to treat congestive heart failure after a heart attack, and is also used to treat high blood pressure (hypertension).

Eplerenone is available under the following different brand names: Inspra.

Dosages of Eplerenone

Dosage Forms and Strengths

Tablet

  • 25 mg
  • 50 mg

Dosage Considerations – Should be Given as Follows:

Hypertension (HTN)

  • Adult and geriatric: Initial 50 mg orally once/day; may increase to 50 mg orally every 12 hours; may take up to four weeks for full therapeutic response; high blood potassium (hyperkalemia) may occur with doses greater than 100 mg/day

Heart Failure Post Myocardial Infarction (MI)

  • Adult and geriatric: Initial 25 mg orally once/day; may titrate to maximum of 50 mg once daily within 4 weeks as tolerated
  • Dose adjustments may be required based on potassium levels

Renal Impairment

  • Contraindicated if CrCl less than 50 mL/min or serum creatinine greater than 2 mg/dL in males or greater than 1.8 mg/dL in females

Hepatic Impairment

  • Dose adjustment not necessary

Dosing considerations

  • In heart attack (myocardial infarction [MI]) congestive heart failure (CHF) patients taking a moderate CYP3A inhibitor, do not exceed 25 mg once daily; in patients with hypertension taking a moderate CYP3A inhibitor, initiate at 25 mg once daily; for inadequate blood pressure response, dosing may be increased to a maximum of 25 mg twice daily
  • Pediatric: Safety and efficacy not established

Other Indications and Uses

  • Improving survival of stable patients with LV systolic dysfunction (LVEF up to 40%) and congestive heart failure (CHF) after an acute heart attack (myocardial infarction [MI])

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