Epoprostenol

  • Brand Name : Flolan
  • Drug Class : PAH, Prostacyclin Analogs
  • Medical Author : Divya Jacob, Pharm. D.
  • Medical Reviewer : Sarfaroj Khan, BHMS, PGD Health Operations
  • _eael_post_view_count : 9

What Is Epoprostenol and How Does It Work?

Epoprostenol is a prescription medication used for the treatment of pulmonary hypertension.

  • Epoprostenol is available under the following different brand names: Flolan, Veletri

What Are Dosages of Epoprostenol?

Adult and pediatric dosage

Injectable, powder for reconstitution

  • 0.5mg/vial
  • 1.5mg/vial

Pulmonary Hypertension

Adult dosage

  • Initial: 2 ng/kg/min IV infusion pump over 24-48 hours; may initiate at a lower dose if intolerant to starting dose  
  • Titrate by 1-2 ng/kg/min every 15 mins or longer, until desired effect or dose-limiting pharmacologic effects occur.

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

What Are Side Effects Associated with Using Epoprostenol?

Common side effects of Epoprostenol include:

  • nausea,
  • vomiting,
  • diarrhea,
  • dizziness,
  • headache,
  • flushing (redness, warmth, or tingly feeling),
  • sweating,
  • stomach pain,
  • jaw pain,
  • muscle or joint pain,
  • injection site reactions (pain, redness, swelling),
  • anxiety,
  • nervousness, or
  • agitation.

Serious side effects of Epoprostenol include:

Rare side effects of Epoprostenol include:

  • none 

This is not a complete list of side effects and other serious side effects or health problems that may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

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