- Brand Name : Integrilin
- Drug Class : , Glycoprotein IIb/IIIa Inhibitors
- Medical Author : Nazneen Memon, BHMS, PGDCR
- Medical Reviewer : Divya Jacob, Pharm. D.
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What Is Eptifibatide and How Does It Work?
Eptifibatide is a prescription medication used for the treatment of acute coronary syndrome (ACS) managed medically or with percutaneous coronary intervention (PCI) and for the treatment of patients undergoing PCI (including intracoronary stenting).
- Eptifibatide is available under the following different brand names: Integrilin
What Are Dosages of Eptifibatide?
Adult dosage
Injection solution
- 2mg/mL
- 0.75mg/mL
Acute Coronary Syndrome
Adult and geriatric dosage
- 180 mcg/kg IV bolus over 1-2 min, THEN
- 2 mcg/kg/min IV continuous infusion; continue infusion until hospital discharge or the initiation of coronary artery bypass graft surgery (CABG), up to 72 hours
- Patient to undergo PCI: infusion should be continued until hospital discharge or for up to 18- 24 hours after the procedure, whichever comes first, allowing for up to 96 hours of therapy
- Administer aspirin (160-325 mg) daily
Percutaneous Coronary Intervention
Adult and geriatric dosage
- 180 mcg/kg IV bolus immediately, THEN
- Continuous infusion 2 mcg/kg/min with another 180 mcg/kg IV bolus 10 minutes after 1st bolus
- Continue infusion until hospital discharge, or for up to 18 to 24 hours, whichever comes first; minimum 12 hr infusion recommended
- In patients who undergo CABG surgery, drug infusion should be discontinued before surgery
- Administer aspirin, 160 to 325 mg, 1 to 24 hours before PCI and daily thereafter
Dosage Considerations – Should be Given as Follows:
- See “Dosages”