Etanercept

  • Brand Name : Enbrel
  • Drug Class : Antipsoriatics, Systemic, DMARDs, TNF Inhibitors
  • Medical Author : Nazneen Memon, BHMS, PGDCR
  • Medical Reviewer : Divya Jacob, Pharm. D.
  • _eael_post_view_count : 11

What Is Etanercept and How Does It Work?

Etanercept is a prescription medicine used to treat the symptoms of ankylosing spondylitisrheumatoid arthritispsoriatic arthritisplaque psoriasis, and juvenile rheumatoid arthritis.

  • Etanercept is available under the following different brand names: Enbrel, ErelziEticovo, etanercept-szzs, etanercept-ykro

What Are Dosages of Etanercept?

Adult and pediatric dosage

Injection solution, prefilled syringe

  • 25mg/0.5mL (Enbrel, Erelzi, Eticovo)
  • 50mg/mL (Enbrel, Erelzi, Eticovo)

Injection solution, prefilled autoinjector

  • 50mg/mL (Enbrel, Erelzi)

Injection, lyophilized powder for reconstitution

  • 25mg/vial (Enbrel)

Injection, prefilled single-dose prefilled cartridge with reusable autoinjector

  • 50mg/mL (Enbrel Mini)

Biosimilars to Enbrel

Erelzi (etanercept-szzs)

Eticovo (etanercept-ykro)

  • Ankylosing Spondylitis
  • Adult dosage
    • 50 mg SC once weekly
  • Rheumatoid Arthritis
  • Adult dosage
    • 50 mg SC once weekly
  • Psoriatic Arthritis
  • Adult dosage
    • 50 mg SC once weekly
  • Plaque Psoriasis
  • Adult dosage
    • Initial: 50 mg SC twice weekly for 3 months
    • Maintenance: 50 mg SC once weekly
  • Pediatric dosage
    • Children below 4 years: Safety and efficacy not established
    • Children above 4 years:
    • Less than 63 kg

Enbrel only

  • 0.8 mg/kg SC weekly; not to exceed 50 mg weekly 
  • More than 63 kg

Enbrel, Eticovo, Erelzi

  • 50 mg SC weekly

Juvenile Rheumatoid Arthritis

Pediatric dosage

  • Children below 2 years: Safety and efficacy not established
  • Children above 2 years (less than 63 kg):
  • Less than 63 kg

Enbrel only

  • 0.8 mg/kg SC weekly; not to exceed 50 mg weekly
  • More than 63 kg

Enbrel, Erelzi, Eticovo

  • 50 mg SC weekly
  • Glucocorticoids, NSAIDs, or analgesics may be continued during treatment

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

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