Hydralazine

  • Brand Name :
  • Drug Class : N/A
  • Medical Author : Sarfaroj Khan, BHMS, PGD Health Operations
  • Medical Reviewer :
  • _eael_post_view_count : 10

What Is Hydralazine and How Does It Work?

Hydralazine is a prescription medication used to treat the symptoms of Severe Essential Hypertension, Chronic Hypertension, Hypertensive Crisis, and Congestive Heart Failure.

  • Hydralazine is available under the following different brand names: Apresoline

What Are Dosages of Hydralazine?

Adult and pediatric dosage

Injectable solution

  • 20mg/mL

Tablets

  • 10mg
  • 25mg
  • 50mg
  • 100mg

Severe Essential Hypertension

  • 10 mg orally every 6 hours for 2-4 days; 25 mg every 6 hours daily for the first week; increase to 50 mg every 6 hours from second week on; adjust dose to lowest effective levels
  • 20-40 mg IM/IV; repeat as necessary
  • Change to oral therapy as soon as possible
  • Pediatric: 1.7-3.5 mg/kg per day IM or IV divided in 4-6 doses

Hypertension (Chronic)

  • Initial: 10 mg orally every 6 hours for 2-4 days; may increase gradually by 10-25 mg/dose every 2-5 days up to 50 mg orally every 6 hours (some patients require 300 mg/day)

Hypertensive Crisis

  • 10-40 mg IV/IM; not to exceed 20 mg/dose; repeat as needed
  • Pregnancy-associated: 5-10 mg IV/IM initially; then 5-10 mg every 20-30 minutes as needed or 0.5-10 mg/hr IV infusion
  • Infants or older: 0.1-0.2 mg/kg IV/IM every 4-6 hours as needed; may increase to usual dose of 1.7-3.5 mg/kg divided every 4-6 hours; not to exceed 20 mg/dose IM or IV or 2 mg/kg every 3-6 hours with cumulative dose not to exceed 9 mg/kg

Congestive Heart Failure

  • Initial dose: 10-25 mg orally every 6-8 hours, titrate dose every 204 weeks
  • Maintenance dose: 225-300 mg/day orally divided every 6-8 hours
  • Infants: 01.-0.5 mg/kg dose IV every 6-8 hours; not to exceed 2 mg/kg
  • Infants and older: 0.75-3 mg/kg per day orally divided every 6-12 hours not to exceed 200 mg/day or 7 mg/kg per day
  • Children and adolescents: 0.15-0.2 mg/kg dose IV every 4-6 hours, not to exceed 20 mg dose

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages.”

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