- Brand Name :
- Drug Class : N/A
- Medical Author : Sarfaroj Khan, BHMS, PGD Health Operations
- Medical Reviewer :
- _eael_post_view_count : 10
What Is Hydralazine and How Does It Work?
Hydralazine is a prescription medication used to treat the symptoms of Severe Essential Hypertension, Chronic Hypertension, Hypertensive Crisis, and Congestive Heart Failure.
- Hydralazine is available under the following different brand names: Apresoline
What Are Dosages of Hydralazine?
Adult and pediatric dosage
Injectable solution
- 20mg/mL
Tablets
- 10mg
- 25mg
- 50mg
- 100mg
Severe Essential Hypertension
- 10 mg orally every 6 hours for 2-4 days; 25 mg every 6 hours daily for the first week; increase to 50 mg every 6 hours from second week on; adjust dose to lowest effective levels
- 20-40 mg IM/IV; repeat as necessary
- Change to oral therapy as soon as possible
- Pediatric: 1.7-3.5 mg/kg per day IM or IV divided in 4-6 doses
Hypertension (Chronic)
- Initial: 10 mg orally every 6 hours for 2-4 days; may increase gradually by 10-25 mg/dose every 2-5 days up to 50 mg orally every 6 hours (some patients require 300 mg/day)
Hypertensive Crisis
- 10-40 mg IV/IM; not to exceed 20 mg/dose; repeat as needed
- Pregnancy-associated: 5-10 mg IV/IM initially; then 5-10 mg every 20-30 minutes as needed or 0.5-10 mg/hr IV infusion
- Infants or older: 0.1-0.2 mg/kg IV/IM every 4-6 hours as needed; may increase to usual dose of 1.7-3.5 mg/kg divided every 4-6 hours; not to exceed 20 mg/dose IM or IV or 2 mg/kg every 3-6 hours with cumulative dose not to exceed 9 mg/kg
Congestive Heart Failure
- Initial dose: 10-25 mg orally every 6-8 hours, titrate dose every 204 weeks
- Maintenance dose: 225-300 mg/day orally divided every 6-8 hours
- Infants: 01.-0.5 mg/kg dose IV every 6-8 hours; not to exceed 2 mg/kg
- Infants and older: 0.75-3 mg/kg per day orally divided every 6-12 hours not to exceed 200 mg/day or 7 mg/kg per day
- Children and adolescents: 0.15-0.2 mg/kg dose IV every 4-6 hours, not to exceed 20 mg dose
Dosage Considerations – Should be Given as Follows:
- See “Dosages.”