Isotretinoin

  • Brand Name : Accutane
  • Drug Class : Acne Agents, Topical, Acne Agents, Systemic, Retinoid-like Agents, Topical
  • Medical Author : John P. Cunha, DO, FACOEP
  • Medical Reviewer :
  • _eael_post_view_count : 9

What Is Isotretinoin Used For?

Isotretinoin is a retinoid indicated for the treatment of severe recalcitrant nodular acne.

Isotretinoin is available under the following different brand names: Amnesteem, Claravis, Myorisan, Absorica, and Zenatane.

Dosages of Isotretinoin

Dosages of Isotretinoin

Adult and Pediatric Dosage Forms and Strengths

Capsule

  • 10mg (Absorica, Amnesteem, Claravis, Myorisan, Zenatane)
  • 20mg (Absorica, Amnesteem, Claravis, Myorisan, Zenatane)
  • 25mg (Absorica)
  • 30mg (Absorica, Claravis)
  • 35mg (Absorica)
  • 40mg (Absorica, Amnesteem, Claravis, Myorisan, Zenatane)

Dosage Considerations – Should be Given as Follows:

Severe, Recalcitrant Nodular Acne

Severe nodular acne unresponsive to conventional therapy, including systemic antibiotics

Adult: 0.5-1 mg/kg/day orally divided twice daily for 15-20 weeks 

Dose up to 2 mg/kg/day (as tolerated) if disease is very severe with scarring or is primarily manifested on the trunk

Children under 12 years: Safety and efficacy not established

Children 12 years and older: 0.5-1 mg/kg/day orally divided twice daily for 15-20 weeks 

Dose up to 2 mg/kg/day (as tolerated) if disease is very severe with scarring or is primarily manifested on the trunk

Dosing considerations

More than 2 months after discontinuation: If warranted by persistent or recurring, severe nodular acne, may initiate a 2nd course of therapy If total nodule count is reduced by greater than 70% prior to completing 15-20 weeks, may discontinue drug

Administration

Swallow capsule whole with full glass of water to reduce esophageal irritation

Amnesteem, Claravis, Myorisan: Take with food (significantly improves absorption)

Absorica: May be taken with or without food

Add to cart