- Brand Name : Accutane
- Drug Class : Acne Agents, Topical, Acne Agents, Systemic, Retinoid-like Agents, Topical
- Medical Author : John P. Cunha, DO, FACOEP
- Medical Reviewer :
- _eael_post_view_count : 9
What Is Isotretinoin Used For?
Isotretinoin is a retinoid indicated for the treatment of severe recalcitrant nodular acne.
Isotretinoin is available under the following different brand names: Amnesteem, Claravis, Myorisan, Absorica, and Zenatane.
Dosages of Isotretinoin
Dosages of Isotretinoin
Adult and Pediatric Dosage Forms and Strengths
Capsule
- 10mg (Absorica, Amnesteem, Claravis, Myorisan, Zenatane)
- 20mg (Absorica, Amnesteem, Claravis, Myorisan, Zenatane)
- 25mg (Absorica)
- 30mg (Absorica, Claravis)
- 35mg (Absorica)
- 40mg (Absorica, Amnesteem, Claravis, Myorisan, Zenatane)
Dosage Considerations – Should be Given as Follows:
Severe, Recalcitrant Nodular Acne
Severe nodular acne unresponsive to conventional therapy, including systemic antibiotics
Adult: 0.5-1 mg/kg/day orally divided twice daily for 15-20 weeks
Dose up to 2 mg/kg/day (as tolerated) if disease is very severe with scarring or is primarily manifested on the trunk
Children under 12 years: Safety and efficacy not established
Children 12 years and older: 0.5-1 mg/kg/day orally divided twice daily for 15-20 weeks
Dose up to 2 mg/kg/day (as tolerated) if disease is very severe with scarring or is primarily manifested on the trunk
Dosing considerations
More than 2 months after discontinuation: If warranted by persistent or recurring, severe nodular acne, may initiate a 2nd course of therapy If total nodule count is reduced by greater than 70% prior to completing 15-20 weeks, may discontinue drug
Administration
Swallow capsule whole with full glass of water to reduce esophageal irritation
Amnesteem, Claravis, Myorisan: Take with food (significantly improves absorption)
Absorica: May be taken with or without food