- Brand Name : Revlimid
- Drug Class : Antineoplastics, Angiogenesis Inhibitor
- Medical Author : Nazneen Memon, BHMS, PGDCR
- Medical Reviewer : Divya Jacob, Pharm. D.
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What Is Lenalidomide and How Does It Work?
Lenalidomide is a prescription medicine used to treat the symptoms of myelodysplastic syndromes (MDS), multiple myeloma (MM), mantle cell lymphoma (MCL), follicular lymphoma (FL), and marginal zone lymphoma (MZL).
- Lenalidomide is available under the following different brand names: Revlimid
What Are Dosages of Lenalidomide?
Adult dosage
Capsule
- 2.5mg
- 5mg
- 10mg
- 15mg
- 25mg
Myelodysplastic Syndromes
Adult dosage
- 10 mg orally once daily; treatment is modified based upon clinical and laboratory findings
- Continue treatment until disease progression or unacceptable toxicity
Multiple Myeloma
Adult dosage
Treatment
- 25 mg orally once daily on Days 1-21 of repeated 28-day cycles (use with dexamethasone)
- Dexamethasone schedule
- 40 mg orally once daily on Days 1-4, 9-12, and 17-20 of each 28-day cycle for the first 4 cycles, THEN
- 40 mg orally once daily on Days 1-4 every 28 days
- Age above 75 years: 20 mg orally once daily on Days 1, 8, 15, and 22 of each 28-day cycle
Maintenance
- Starting dose: 10 mg orally once daily continuously (i.e., Day 1-28 of repeated 28-day cycles) until disease progression or unacceptable toxicity
- After 3 cycles: May increase dose to 15 mg orally once daily if tolerated
Mantle Cell Lymphoma
Adult dosage
- 25 mg orally once daily on Days 1-21 of repeated 28-day cycles; treatment is modified based on clinical or laboratory findings
- Continue until disease progression or unacceptable toxicity
Follicular Lymphoma or Marginal Zone Lymphoma
Adult dosage
- Rituximab 375mg/m² IV every Week in Cycle 1 (Days 1, 8, 15, and 22) on Day 1 of every 28-day cycle from Cycles 2-5
- Lenalidomide 20 mg orally once daily on Days 1-21 every 28 days up to 12 cycles
Dosage Considerations – Should be Given as Follows:
- See “Dosages”