Lenalidomide

  • Brand Name : Revlimid
  • Drug Class : Antineoplastics, Angiogenesis Inhibitor
  • Medical Author : Nazneen Memon, BHMS, PGDCR
  • Medical Reviewer : Divya Jacob, Pharm. D.
  • _eael_post_view_count : 7

What Is Lenalidomide and How Does It Work?

Lenalidomide is a prescription medicine used to treat the symptoms of myelodysplastic syndromes (MDS), multiple myeloma (MM), mantle cell lymphoma (MCL), follicular lymphoma (FL), and marginal zone lymphoma (MZL).

  • Lenalidomide is available under the following different brand names: Revlimid

What Are Dosages of Lenalidomide?

Adult dosage

Capsule

  • 2.5mg
  • 5mg
  • 10mg
  • 15mg
  • 25mg

Myelodysplastic Syndromes

Adult dosage

  • 10 mg orally once daily; treatment is modified based upon clinical and laboratory findings
  • Continue treatment until disease progression or unacceptable toxicity

Multiple Myeloma

Adult dosage

Treatment

  • 25 mg orally once daily on Days 1-21 of repeated 28-day cycles (use with dexamethasone)
  • Dexamethasone schedule
    • 40 mg orally once daily on Days 1-4, 9-12, and 17-20 of each 28-day cycle for the first 4 cycles, THEN
    • 40 mg orally once daily on Days 1-4 every 28 days
    • Age above 75 years: 20 mg orally once daily on Days 1, 8, 15, and 22 of each 28-day cycle

Maintenance

  • Starting dose: 10 mg orally once daily continuously (i.e., Day 1-28 of repeated 28-day cycles) until disease progression or unacceptable toxicity
  • After 3 cycles: May increase dose to 15 mg orally once daily if tolerated

Mantle Cell Lymphoma

Adult dosage

  • 25 mg orally once daily on Days 1-21 of repeated 28-day cycles; treatment is modified based on clinical or laboratory findings
  • Continue until disease progression or unacceptable toxicity

Follicular Lymphoma or Marginal Zone Lymphoma

Adult dosage

  • Rituximab 375mg/m² IV every Week in Cycle 1 (Days 1, 8, 15, and 22) on Day 1 of every 28-day cycle from Cycles 2-5  
  • Lenalidomide 20 mg orally once daily on Days 1-21 every 28 days up to 12 cycles

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

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