Macitentan

  • Brand Name : Opsumit
  • Drug Class : PAH, Endothelin Antagonists
  • Medical Author : Dr. Vinod Katiboina, Pharm. D.
  • Medical Reviewer : Divya Jacob, Pharm. D.
  • _eael_post_view_count : 12

What Is Macitentan and How Does It Work?

Macitentan is a prescription medication used for the treatment of pulmonary arterial hypertension (PAH, WHO Group I) to reduce the risk of disease progression and hospitalization. 

  • Macitentan is available under the following different brand names: Opsumit

What Are Side Effects Associated with Using Macitentan?

Common side effects of Macitentan include:

  • Low red blood cell count (anemia),

Common cold-like symptoms (stuffy nose or sore throat),

Serious side effects of Macitentan include:

  • Dark urine, 
  • Persistent nausea/vomiting/loss of appetite, 
  • Stomach/abdominal pain, yellowing eyes/skin.
  • Rash,
  • Itching/swelling (especially of the face/tongue/throat), 
  • Severe dizziness, and trouble breathing.

Rare side effects of Macitentan include:

  • none 

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

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