Maralixibat

  • Brand Name : Livmarli
  • Drug Class : N/A
  • Medical Author : Dr. Vinod Katiboina, Pharm. D.
  • Medical Reviewer : Divya Jacob, Pharm. D.
  • _eael_post_view_count : 11

What Is Maralixibat and How Does It Work?

Maralixibat is a prescription medication used for the treatment of cholestatic pruritus (itching) in patients with Alagille syndrome. 

  • Maralixibat is available under the following different brand names: Livmarli.

What Are the Side Effects Associated with Using Maralixibat?

Common side effects of Maralixibat include:

  • Diarrhea,
  • Abdominal pain,
  • Vomiting,
  • Fat-soluble vitamin deficiency (a, d, e, or k deficiency), and
  • Increased transaminases

Serious side effects of Maralixibat include:

  • Hives,
  • Difficulty breathing,
  • Swelling of the face, lips, tongue, or throat,
  • Changes or worsening liver test results,
  • Nausea,
  • Vomiting,
  • Yellowing of the skin or eyes (jaundice),
  • Dark or brown urine,
  • Pain in the right side of the abdomen,
  • Loss of appetite,
  • Diarrhea,
  • Stomach pain,
  • Bone fractures, and
  • Gastrointestinal bleeding

Rare side effects of Maralixibat include:

  • None 

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

What Are the Dosages of Maralixibat?

Adult and pediatric dosage

Oral solution

  • 9.5 mg/ml

Cholestatic Pruritus

Adult and pediatric dosage

  • Days 1-7: 190 mcg/kg orally once a day
  • Beginning Day 8: Increase to 380 mcg/kg orally once a day, as tolerated; not to exceed 28.5 mg/day for patients weighing above 70 kg.
  • Administer 30 minutes before the first meal of the day.

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

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