- Brand Name : Vabomere
- Drug Class : Carbapenems
- Medical Author : John P. Cunha, DO, FACOEP
- Medical Reviewer :
- _eael_post_view_count : 10
What Is Meropenem/Vaborbactam and How Does It Work?
Meropenem/vaborbactam is used for complicated urinary tract infections (cUTIs), including pyelonephritis caused by the following susceptible microorganisms: Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae species complex in adults 18 years and older.
Meropenem/vaborbactam is available under the following different brand names: Vabomere.
What Are the Dosages of Meropenem/Vaborbactam?
Dosages of Meropenem/Vaborbactam:
Dosage Forms and Strengths
Injection, Sterile Powder for Reconstitution
- (1g/1g)/vial: 2 g
Dosage Considerations – Should be Given as Follows:
Urinary Tract Infections
- Indicated for complicated urinary tract infections (cUTIs), including pyelonephritis caused by the following susceptible microorganisms: Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae species complex in adults 18 years and older
- 4 g (meropenem [2g]/vaborbactam [2g]) intravenously (IV) every 8 hours for up to 14 days; infuse over 3 hours
Dosage Modifications
Renal impairment
- Treatment duration for all doses: Up to 14 days
- eCrCl greater than 50 mL/min/1.73²: No dosage adjustment necessary
- eCrCl 30-49 mL/min/1.73²: 2 g (meropenem [1g]/vaborbactam [1g]) IV every 8 hours
- eCrCl 15-29 mL/min/1.73²: 2 g (meropenem [1g]/vaborbactam [1g]) IV every 12 hours
- eCrCl less than 15 mL/min/1.73²: 1 g (meropenem [0.5g]/vaborbactam [0.5g]) IV every 12 hours
- Dose adjustments for renal impairment should be administered after hemodialysis session
Dosing Considerations
- Meropenem is known to be substantially excreted by the kidneys, and the risk of adverse reactions may be greater in patients with renal impairment
- Geriatric patients are more likely to have decreased renal function; use caution in dose selection and monitor if necessary
- Children under 18 years: Safety and efficacy not established