Metaxalone

Metaxalone is a prescription medication used for the treatment of musculoskeletal pain.

• Metaxalone is available under the following different brand names: Skelaxin

Adult and pediatric dosage

Tablet

• 400mg
• 800mg

Musculoskeletal Pain

Adult dosage

• 800 mg orally every 6-8 hours

Pediatric dosage

• Children below 12 years: Safety and efficacy not established
• Children above 12 years: 800 mg orally every 6-8 hours

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”

Common side effects of Metaxalone include:

• drowsiness,
• dizziness,
• headache,
• nervousness,
• irritability,
• nausea,
• vomiting,
• upset stomach, or
• skin rash.

Serious side effects of Metaxalone include:

• stomach pain,
• loss of appetite,
• low fever,
• dark urine,
• clay-colored stools, and
• yellowing skin and eyes (jaundice).

Rare side effects of Metaxalone include:

• none 

This is not a complete list of side effects and other serious side effects or health problems that may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Metaxalone has severe interactions with no other drugs.
• Metaxalone has serious interactions with the following drugs:
  • abametapir
  • apalutamide
  • benzhydrocodone/acetaminophen
  • calcium/magnesium/potassium/sodium oxybates
  • fexinidazole
  • hydrocodone
  • idelalisib
  • ivosidenib
  • lopinavir
  • metoclopramide intranasal
  • sodium oxybate
  • sufentanil SL
  • tucatinib
  • voxelotor
• Metaxalone has moderate interactions with at least 174 other drugs.
• Metaxalone has minor interactions with the following drugs:
  • eucalyptus
  • levoketoconazole
  • ribociclib
  • sage

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns.