Microbiota Rectal

Microbiota Rectal is a prescription medication used to prevent the recurrence of Clostridioides difficile infection.

• Microbiota Rectal is available under the following different brand names: Rebyota, rectal microbiota live-jslm

Common side effects of Microbiota Rectal include:

• abdominal pain,
• diarrhea,
• abdominal distention,
• gas (flatulence), and
• nausea.

Serious side effects of Microbiota Rectal include:

• hives,
• difficulty breathing,
• swelling of the face, lips, tongue, or throat,

Rare side effects of Microbiota Rectal include:

• none

Seek medical care or call 911 at once if you have the following serious side effects:

• Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
• Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out. 

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

Adult dosage

Rectal suspension

• Each 150mL dose contains between 1×108 and 5×1010 colony-forming units (CFU) per mL of fecal microbes, including more than 1×105 CFU/mL of Bacteroides
• Fecal matter suspended in polyethylene glycol (PEG) 3350 and 0.9% NaCl solution

Clostridioides difficile Infection

Adult dosage

• 150 mL rectally as a single dose

Dosage Considerations – Should be Given as Follows: 

• See “Dosages”