Midostaurin

  • Brand Name : Rydapt
  • Drug Class : Antineoplastic Tyrosine Kinase Inhibitors
  • Medical Author : Divya Jacob, Pharm. D.
  • Medical Reviewer : Sarfaroj Khan, BHMS, PGD Health Operations
  • _eael_post_view_count : 7

What Is Midostaurin and How Does It Work?

Midostaurin is a prescription medication used for the treatment of acute myeloid leukemia and systemic mastocytosis.

  • Midostaurin is available under the following different brand names: Rydapt

What Are Side Effects Associated with Using Midostaurin?

Common side effects of Midostaurin include:

  • low blood cell counts,
  • fever,
  • bruising,
  • nosebleeds,
  • high blood sugar,
  • infection around a needle injection,
  • mouth sores,
  • cold symptoms (stuffy nose, sneezing, sore throat),
  • trouble breathing,
  • nausea,
  • vomiting,
  • stomach pain,
  • constipation,
  • diarrhea,
  • muscle or bone pain,
  • headache,
  • tiredness, and
  • swelling in the hands, feet, or ankle

Serious side effects of Midostaurin include:

  • hives,
  • difficulty breathing,
  • swelling of the face, lips, tongue, or throat,
  • warmth,
  • redness,
  • tingly feeling,
  • chest pain,
  • pain or sores in or around the mouth,
  • redness inside the mouth,
  • sore throat,
  • wheezing,
  • dry cough,
  • shortness of breath,
  • bruising, swelling, warmth, redness, oozing, or bleeding around the needle,
  • increased thirst,
  • increased urination,
  • dry mouth,
  • fruity breath odor,
  • fever,
  • chills,
  • tiredness,
  • skin sores,
  • easy bruising,
  • unusual bleeding,
  • pale skin,
  • cold hands and feet, and
  • lightheadedness

Rare side effects of Midostaurin include:

  • none 

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

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