- Brand Name : Nafcillin
- Drug Class : Penicillins, Penicillinase-Resistant
- Medical Author : Nazneen Memon, BHMS, PGDCR
- Medical Reviewer : Divya Jacob, Pharm. D.
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What Is Nafcillin and How Does It Work?
Nafcillin is a prescription medicine used to treat a wide variety of bacterial infections including infections caused by penicillinase-producing staphylococci.
- Nafcillin is available under the following different brand names: Nafcil, Nallpen
What Are Dosages of Nafcillin?
Adult and pediatric dosage
Injectable solution
- 20mg/mL
- 2g/100mL
Powder for injection
- 1g
- 2g
- 10g
Susceptible Infections
Adult dosage
- 500 mg IV/IM every 4-6 hours
Pediatric dosage
- 50-100 mg/kg/day IV/IM divided every 6 hours
Maximum 12g/day
Severe Infections
Adult dosage
- 1 g IV/IM every 4 hours
Pediatric dosage
- 100-200 mg/kg/day IV/IM divided every 6 hours
Staphylococcal Endocarditis
Adult dosage
- 2 g IV every 4 hours for 4-6 weeks; may be longer and may add rifampin and gentamicin if prosthetics present
Pediatric dosage
- 200mg/kg/day IV divided every 4-6 hours for 6 weeks; may be longer and may add rifampin and gentamicin if prosthetics present
Neonates (less than 28 Days Old)
- (Less than 7 days old, less than 2 kg) OR (more than 7 days old, less than 1.2 kg): 50 mg/kg/day IV/IM divided every 12 hours
- (Less than 7 days old, more than 2 kg) OR (more than 7 days old, 1.2-2 kg): 75 mg/kg/day IV/IM divided every 8 hours
- (more than 7 days old, more than 2 kg): 100-140 mg/kg/day IV/IM divided every 6 hours
Adult dosage
- 2 g IV every 4 hours
Dosage Considerations – Should be Given as Follows:
- See “Dosages”