Naproxen-Sumatriptan

  • Brand Name : Treximet
  • Drug Class : Antimigraine Agents, NSAIDs
  • Medical Author : Divya Jacob, Pharm. D.
  • Medical Reviewer :
  • _eael_post_view_count : 9

What Is Naproxen and Sumatriptan and How Does It Work?

Naproxen and Sumatriptan are combination prescription medications used to treat migraine headaches. 

  • Naproxen and Sumatriptan are available under various brand names: Treximet

What Are Side Effects Associated with Using Naproxen and Sumatriptan?

Common side effects of Naproxen and Sumatriptan include:

  • dizziness, drowsiness, feeling weak or tired.
  • irregular heartbeats.
  • numbness or tingling in your fingers or toes.
  • dry mouth, heartburn, nausea.
  • feeling hot; or
  • tight muscles, pain, or pressure in your chest or throat.

Serious side effects of Naproxen and Sumatriptan include:

  • hives, 
  • difficult breathing, 
  • swelling in the face or throat.
  • severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
  • numbness, tingling, pale or blue-colored appearance in the fingers or toes.
  • leg cramps, burning, coldness, or heavy feeling in the feet or legs.
  • severe headache, blurred vision, pounding in the neck or ears.
  • a seizure.
  • heart problems–swelling, rapid weight gain, feeling short of breath.
  • high levels of serotonin in the body–agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, diarrhea.
  • kidney problems–little or no urination, swelling in the feet or ankles, feeling tired or short of breath.
  • liver problems–loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
  • low red blood cells (anemia)–pale skin, unusual tiredness, feeling light-headed or short of breath.
  • signs of stomach bleeding–bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
  • stomach problems–sudden severe stomach pain (especially after eating), vomiting, constipation, bloody diarrhea, weight loss.

Rare side effects of Naproxen and Sumatriptan include:

  • none

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

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