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Neratinib

  • Brand Name : Nerlynx
  • Drug Class : Antineoplastics EGFR Inhibitors, Antineoplastic Tyrosine Kinase Inhibitors, Antineoplastics, Anti-HER2
  • Medical Author : Dr. Vinod Katiboina, Pharm. D.
  • Medical Reviewer : Divya Jacob, Pharm. D.
  • _eael_post_view_count : 5

What Is Neratinib and How Does It Work?

Neratinib is a prescription medication used for the treatment of Breast Cancer.

  • Neratinib is available under the following different brand names: Nerlynx.

What Are Side Effects Associated with Using Neratinib?

Common side effects of Neratinib include:

  • Diarrhea
  • Nausea
  • Stomach-area (abdomen) pain
  • Tiredness
  • Vomiting
  • Rash
  • Dry or inflamed mouth, or mouth sores
  • Decreased appetite.
  • Muscle spasms
  • Upset stomach.
  • Nail problems including color change.
  • Dry skin
  • Swelling of the stomach-area
  • Nosebleed
  • Weight loss
  • Urinary tract infection

Serious side effects of Neratinib include:

Rare side effects of Neratinib include:

  • None 

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out. 

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

What Are the Dosages of Neratinib?

Adult dosage

Tablet

  • 40 mg (equivalent to 48.31mg neratinib maleate)

Breast Cancer

Adult dosage

  • Early-stage breast cancer
    • 240 mg (6 tablets) orally once a day continuously for 1 year.
    • Consider a two-week dose escalation instead of starting at the 240-mg daily dose to minimize severe diarrhea if not using antidiarrheal prophylaxis
  • Advanced or metastatic breast cancer
    • Consider a two-week dose escalation instead of starting at the 240-mg daily dose to minimize severe diarrhea if not using antidiarrheal prophylaxis
    • Each cycle is 21 days.
      • Days 1-21: 240 mg orally once a day PLUS
      • Days 1-14: Capecitabine 750 mg/m2 orally two times a day
      • Continue until disease progression or unacceptable toxicities.
    • Dose escalation regimen
      • Days 1 to 7: 120 mg orally once a day
      • Days 8 to 14: 160 mg orally once a day
      • Day 15 and thereafter: 240 mg orally once a day; continue for up to 1 year.
      • If diarrhea occurs, treat it with antidiarrheal medications, fluids, and electrolytes as clinically warranted.

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

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