- Brand Name : Orfadin
- Drug Class : Metabolic & Endocrine, Other
- Medical Author : Divya Jacob, Pharm. D.
- Medical Reviewer : Sarfaroj Khan, BHMS, PGD Health Operations
- _eael_post_view_count : 4
What Is Nitisinone and How Does It Work?
Nitisinone is a prescription medication used for the treatment of hereditary tyrosinemia type 1 (HT-1) as an adjunct to dietary restriction of tyrosine and phenylalanine.
- Nitisinone is available under the following different brand names: Orfadin, Nityr
What Are Side Effects Associated with Using Nitisinone?
Common side effects of Nitisinone include:
- vision changes,
- light sensitivity,
- eye pain,
- red or puffy eyes,
- nosebleeds,
- increased sensitivity of the eyes to light,
- rash,
- itching,
- dry or peeling skin, and
- thinning hair
Serious side effects of Nitisinone include:
- hives,
- difficulty breathing,
- swelling of the face, lips, tongue, or throat,
- sudden change in behavior, ability, or development (sitting up, crawling, walking, talking),
- easy bruising,
- unusual bleeding (nose, mouth, vagina, or rectum),
- purple or red pinpoint spots under the skin,
- nausea,
- diarrhea,
- upper stomach pain,
- itching,
- loss of appetite,
- dark urine,
- clay-colored stools,
- yellowing of the skin or eyes (jaundice),
- vision problems,
- eye pain,
- redness or swelling, burning, white or yellow patches on the eyes, and
- calluses, peeling, or hardened skin on the palms of the hands or the soles of the feet
Rare side effects of Nitisinone include:
- none
Seek medical care or call 911 at once if you have the following serious side effects:
- Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
- Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
- Serious heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.
This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.